Dr. Jayshree Mishra's Research

Regulation of efflux transporters in obesity

Obesity is a global health epidemic and it increases the risk of obesity associated malignancies including colorectal cancer. Under normal physiological condition, mucosal detoxification system present in our gastrointestinal tract helps in eliminating the dietary toxins from food, drugs and metabolites by neutralizing the toxic effect. However, in chronic low grade inflammatory condition as seen in obesity leads to altered drug metabolism and disposition which has a profound impact on the pharmacotherapy of widely used clinically relevant medications in terms of safety and efficacy and increased toxicity that increases the risk of obesity associated cancer. My research focuses on understanding the regulation of the efflux transporters under normal physiological condition as well as in chronic low grade inflammatory condition as seen in obesity. A better understanding of the mechanistic details underlying the regulation of colonic efflux transporters in obesity will contribute towards development of powerful in vitro and in vivo tools in predicting the drug response and option for better drug design and development.