Lin Zhu

Lin Zhu

Assistant Professor Department of Pharmaceutical Sciences

Texas A&M Rangel College of Pharmacy
1010 W. Ave. B
Kingsville, Texas   78363

Phone: 361-221-0757 / 361-221-0740 (lab)
Fax: 361-221-0793
lzhu@tamhsc.edu

Education and Training

Northeastern University, School of Pharmacy
American Cancer Society Postdoctoral Fellow, 2013

Northeastern University, School of Pharmacy
Postdoctoral Research Associate, 2010-2012

University of Tennessee Health Science Center
Ph.D., Pharmaceutics, 2010

China Pharmaceutical University, China
M.S., Pharmaceutics, 2003

China Pharmaceutical University, China
B.E., Pharmaceutics, 1997

Teaching Interests

  • Pharmaceutics
  • Dosage forms and drug delivery systems
  • Biopharmaceutics
  • Pharmacokinetics
  • Nanomedicine

Research Interests

  • Development of novel drug delivery systems and nanomedicine for small and macro molecules.
  • Design and synthesis of functional polymers/conjugates for drug delivery.
  • Targeted and stimulus-responsive delivery of therapeutic and imaging agents.
  • In vitro and in vivo characterization of drug delivery systems/therapeutics.
  • Cancer therapy.

Selected Publications

  • Tu Y, Zhu L*, Lipids and Their Derivatives: By-products Used as Essential Building Blocks for Modern Drug Delivery Systems, Current Drug Targets, 2014, 15(5), 502-517.
  • Zhu L, Perche F, Wang T, Torchilin VP, Matrix Metalloproteinase 2-sensitive Multifunctional Polymeric Micelles for Tumor-specific Co-delivery of siRNA and Hydrophobic Drugs, Biomaterials, 2014, 35 (13), 4213-4222.
  • Perche F, Biswas S, Wang T, Zhu L, Torchilin VP, Hypoxia-targeted siRNA Delivery, Angewandte Chemie International Edition, 2014, 53(13), 3362-6.
  • Zhu L, Torchilin VP, Stimuli-Sensitive Nanopreparations for Tumor Targeting, Integrative Biology, 2013, 5, 96-107.
  • Zhu L, Wang T, Perche F, Taigind A, Torchilin VP, Enhanced Anticancer Activity of Nanopreparation Containing a Novel MMP2-sensitive PEG-drug Conjugate and Cell-penetrating Moiety, Proceedings of the National Academy of Sciences, 2013,110 (42), 17047-17052
  • Wu H, Zhu L, Torchilin, VP, pH-Sensitive Poly(histidine)-PEG/DSPE-PEG Copolymer Micelles for Cytosolic Drug Delivery, Biomaterials, 2013, 34(4):1213-1222.
  • Zhu L, Kate P, Torchilin VP, Matrix Metalloprotease 2-Responsive Multifunctional Liposomal Nanocarrier for Enhanced Tumor Targeting, ACS Nano, 2012, 6 (4), 3491–3498
  • Zhu L, Mahato R, Targeted Delivery of siRNA to Hepatocytes and Hepatic Stellate Cells by Bioconjugation, Bioconjugate Chemistry, 2010, 21(11),2119-2127.
  • Zhu L, Huo Z, Wang L, Tong X, Xiao Y, Ni Y, Targeted Delivery of Methotrexate to Skeletal Muscular Tissue by Thermosensitive Magnetoliposomes, International Journal of Pharmaceutics, 2009, 370(1-2),136-143.
  • Zhu L, Lu Y, Miller DD, Mahato RI, Structural and Formulation Factors Influencing Pyridinium Lipid-based Gene Transfer, Bioconjugate Chemistry,2008, 19 (12), 2499-2512.
  • Zhu L, Ye Z, Cheng K, Miller DD and Mahato RI, Site-specific delivery of oligonucleotides to hepatocytes after systemic administration. Bioconjugate Chem., 2008, 19(1), 290-298.

Selected Patents

  • Zhu L, Perche F, Torchilin VP, “Copolymers for the delivery of drugs into cells”, November 30, 2012 (U.S. No. 61/731,951 & International No. PCT/US2013/072216)
  • Zhu L, Torchilin VP, “System for delivery of siRNA and co-delivery of siRNA and drug into MMP-expressing cells” November 4, 2013 (U.S. No. 61/899,511)

National Service & Recognition

  • Controlled Release Society (CRS) T. Nagai Postdoctoral Research Achievement Award, 2014
  • American Cancer Society-Ellison Foundation Postdoctoral Fellowship, 2013
  • AAPS Graduate Student Symposium Award in Biotechnology, 2009
  • University of Tennessee Student Travel Award, 2009
  • AAPS Travel Awards in Biotechnology, 2008 & 2009