M. N. V. Ravi Kumar

M. N. V. Ravi Kumar

Professor of Pharmaceutical Sciences

Texas A&M Irma Lerma Rangel College of Pharmacy
Mail Stop 1114
310B Reynolds Medical Building
College Station, Texas   77843

Phone: 979.436.0721
Fax: 979.436.0719
mnvrkumar@tamhsc.edu

Education and Training

Indian Institute of Technology, Roorkee
PhD, Drug Delivery, 2000      

Devi Ahilya Viswha Vidyalaya, India
Master of Science, Applied Chemistry, 1996

Nagarjuna University, India
Bachelor of Science, Physical Sciences, 1992

Research Interests

My groups' research projects are centered on the interface of biomaterials and therapeutics at the nano-micro or macro-scale to prevent, manage or treat diseases using drugs or drug-like compounds or their combinations. The idea is to apply innovative delivery strategies to the existing small or large molecules for improving the risk vs benefit ratio; realize new indications or apply the innovative delivery technologies early on in the drug discovery program to minimize the attrition rates.

Selected Publications

  • Urolithin A mitigates cisplatin-induced nephrotoxicity by inhibiting renal inflammation and apoptosis in an experimental rat model. Guada M, Ganugula R, Vadhanam M, Kumar MNVR. JPharmacol Exp Ther. 2017 Aug 7. pii: jpet.117.242420. doi: 10.1124/jpet.117.242420. [Epub ahead of print] PMID: 28784820 (Cover Article)

  • Ex Vivo rat eye model for investigating transport of next generation precision-polyester nanosystems. Ganugula R, Arora M, Kumar MNVR. ACS Appl Mater Interfaces. 2017 Aug 9;9(31):25668-25671. doi: 10.1021/acsami.7b07896. Epub 2017 Jul 26. PMID: 28737886

  • Nano-curcumin safely prevents streptozotocin-induced inflammation and apoptosis in pancreatic beta cells for effective management of Type 1 diabetes mellitus. Ganugula R, Arora M, Jaisamut P, Wiwattanapatapee R, Jørgensen HG, Venkatpurwar VP, Zhou B, Rodrigues Hoffmann A, Basu R, Guo S, Kumar MNVR. Br J Pharmacol. 2017 Jul;174(13):2074-2084. doi: 10.1111/bph.13816. Epub 2017 May 30. PMID: 28409821.

  • Next generation precision-polyesters enabling optimization of ligand-receptor stoichiometry for modular drug delivery. Ganugula R, Arora M, Saini P, Guada M, Kumar MNVR. J Am Chem Soc. 2017 May 31;139(21):7203-7216. doi: 10.1021/jacs.6b13231. Epub 2017 Apr 19. PMID: 28395139 (Cover Article)

  • Noncompetitive active transport exploiting intestinal transferrin receptors for oral delivery of proteins by tunable nanoplatform. Ganugula R, Arora M, Guada M, Saini P, Kumar MNVR. ACS Macro Lett. 6 (2), 161-164. DOI: 10.1021/acsmacrolett.7b00035. (Cover Article)

  • The next generation non-competitive active polyester nanosystems for transferrin receptor-mediated peroral transport utilizing gambogic acid as a ligand. Saini P, Ganugula R, Arora M, Kumar MNVR.Sci Rep. 2016 Jul 8;6:29501. doi: 10.1038/srep29501.